Brand  (β version)

PDB ID: 6GMC

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Ligands
Code Name Style Show Link
C7C 5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylate PoSSuM
EDO 1,2-ethanediol PoSSuM
FMN Flavin mononucleotide PoSSuM
Non-standard Residues
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Structure summary

Code : 6GMC   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : 1.2 A resolution structure of human hydroxyacid oxidase 1 bound with FMN and 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole
Release Data : 2018-06-13
Compound :
mol_id molecule chains synonym
1 Hydroxyacid oxidase 1 A HAOX1,Glycolate oxidase,GOX
ec: 1.1.3.15
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HAO1, GOX1, HAOX1
Authors : MacKinnon, S., Bezerra, G.A., Krojer, T., Smee, C., Arrowsmith, C.H., Edwards, E., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W.
Keywords : glycolate, glyoxylate, peroxisome, FMN, primary hyperoxaluria, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.2000 Å )
Citation :

Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate

MacKinnon, S.,Bezerra, G.A.,Krojer, T.  et al.
To Be Published 

Reaction

Chain : A
UniProt : Q9UJM8 (HAOX1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2 1.1.3.15 PubMed:10777549, PubMed:17669354, PubMed:18215067
left-to-right PubMed:10777549
glycolate + O2 = glyoxylate + H2O2 1.1.3.15 PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067
left-to-right PubMed:10978532, PubMed:17669354
glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate 1.2.3.5 PubMed:10777549, PubMed:17669354, PubMed:18215067
left-to-right PubMed:17669354
2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2 - PubMed:10777549, PubMed:18215067
left-to-right PubMed:10777549
2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2 - PubMed:10777549, PubMed:18215067
left-to-right PubMed:10777549