Brand  (β version)

PDB ID: 6GLJ

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Ligands
Code Name Style Show Link
F3E 4-phenylpyrimidin-2-amine PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6GLJ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the absence of acetate
Release Data : 2019-02-20
Compound :
mol_id molecule chains synonym
1 7,8-dihydro-8-oxoguanine triphosphatase A 2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1
ec: 3.6.1.55,3.6.1.56
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: NUDT1, MTH1
Authors : Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.
Keywords : Inhibitor, Complex, Hydrolase, DNA repair, Fragment
Exp. method : X-RAY DIFFRACTION ( 1.301 Å )
Citation :

hMTH1 F27A in complex with TH scaffold 1.

Eberle, S.A.,Wiedmer, L.,Sledz, P.  et al.
To Be Published 

Reaction

Chain : A
UniProt : P36639 (8ODP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+) 3.6.1.56 PubMed:10373420, PubMed:10608900, PubMed:11139615, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:21787772, PubMed:22556419, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004, PubMed:30304478, PubMed:7782328, PubMed:8226881
left-to-right PubMed:10373420
2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+) - PubMed:11139615
left-to-right
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+) - PubMed:10373420, PubMed:10608900, PubMed:11139615, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:21787772, PubMed:22556419, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004, PubMed:30304478, PubMed:7782328, PubMed:8226881
left-to-right PubMed:10373420
8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+) - PubMed:11139615
left-to-right
H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl- dGMP - PubMed:30304478
left-to-right
H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl- dAMP - PubMed:32144205
left-to-right
H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP - PubMed:32144205
left-to-right