Het-PDB Navi2 (PDB: 6GJW)

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Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM
F2H	4-[[3-[[3-[(4,8-disulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]phenyl]carbonylamino]naphthalene-1,5-disulfonate				PoSSuM

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Download interaction data: 6GJW

Code :

6GJW PDBj RCSB PDB PDBe

Header :

APOPTOSIS

Title :

Structure of XIAP-BIR1 domain in complex with an NF023 analog

Release Data :

2019-05-29

Compound :

mol_id	molecule	chains	synonym
1	E3 ubiquitin-protein ligase XIAP	A,B,C,D	Baculoviral IAP repeat-containing protein 4,IAP-like protein,hILP,Inhibitor of apoptosis protein 3,hIAP3,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein,X-linked IAP
	ec: 2.3.2.27

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: XIAP, API3, BIRC4, IAP3

Authors :

Sorrentino, L., Cossu, F., Malkoc, B., Zaffaroni, M., Milani, M., Mastrangelo, E.

Keywords :

BIR; NF-KB; XIAP; CANCER; APOPTOSIS; DOCKING; INHIBITOR, APOPTOSIS

Exp. method :

X-RAY DIFFRACTION ( 1.9000 Å )

Citation :

Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1.

Sorrentino, L.,Cossu, F.,Milani, M. et al.
(2019) Chemistryopen 8 : 476 - 482

Chain :

A, B, C, D

UniProt :

P98170 (XIAP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.	2.3.2.27	PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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PDB ID: 6GJW