Brand  (β version)

PDB ID: 6GJK

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Ligands
Code Name Style Show Link
1PE Pentaethylene glycol PoSSuM
ACT Acetate ion PoSSuM
F0Z 2-(1,4,5,6-tetrahydropyrimidin-2-yl)benzenethiol PoSSuM
K Potassium ion PoSSuM
MLT D-malate PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6GJK   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : A degradation product of PD 404182 (P2742) bound to Histone Deacetylase-like Amidohydrolase
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 Histone deacetylase-like amidohydrolase A,B HDAH
ec: 3.5.1.-
mutation: H257P
Source :
mol_id organism_scientific expression_system
1 Alcaligenaceae bacterium FB188  (taxid:242601) Escherichia coli BL21  (taxid:511693)
gene: hdaH, hdaH1
expression_system_plasmid: pET
Authors : Kraemer, A., Meyer-Almes, F.J.
Keywords : HDAH, HDAC, P2742, PD 404182, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, HISTONE DEACETYLASE, covalent modification, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.47 Å )
Citation :

Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.

Muth, M.,Jansch, N.,Kopranovic, A.  et al.
(2019)  Biochim Biophys Acta Gen Subj  1863 : 577 - 585

PubMed: 30611847
DOI: 10.1016/j.bbagen.2019.01.001

Reaction

Chain : A, B
UniProt : Q70I53 (HDAH_ALCSD)
Reaction : -