Brand  (β version)

PDB ID: 6GJG

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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
F1T 3,6-dimethyl-~{N}-[4-(trifluoromethyl)phenyl]-[1,2]oxazolo[5,4-D]pyrimidin-4-amine PoSSuM
Non-standard Residues
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Structure summary

Code : 6GJG   PDBj   RCSB PDB   PDBe
Header : FLAVOPROTEIN
Title : Plasmodium falciparum dihydroorotate dehydrogenase DHODH in complex with 3,6-dimethyl-N-(4-(trifluoromethyl)phenyl)-(1,2)oxazolo(5,4-D)pyrimidin-4-amine
Release Data : 2018-09-19
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A,B DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
Source :
mol_id organism_scientific organism_common expression_system
1 Plasmodium falciparum  (taxid:36329) Isolate 3D7 Escherichia coli  (taxid:562)
gene: PFF0160c
Authors : Rowland, P.
Keywords : Enzyme, DHODH, FLAVOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.99 Å )
Citation :

Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity.

Kokkonda, S.,El Mazouni, F.,White, K.L.  et al.
(2018)  ACS Omega  3 : 9227 - 9240

PubMed: 30197997
DOI: 10.1021/acsomega.8b01573

Reaction

Chain : A, B
UniProt : Q08210 (PYRD_PLAF7)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = orotate + a quinol 1.3.5.2 -
-
Cofactor: Evidence: Note:
FMN ECO:0000269 | PubMed:16510978
ECO:0000269 | PubMed:19640844
ECO:0000269 | PubMed:20702404
Binds 1 FMN per subunit.