Brand  (β version)

PDB ID: 6GJD

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
F0E Cyclooctyl ~{N}-[3-[[4-[5-[[(3~{R})-1-[2-oxidanylidene-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]pyrrolidin-3-yl]carbonylamino]-1~{H}-indazol-3-yl]pyridin-2-yl]carbonylamino]propyl]carbamate PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Modification
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Structure summary

Code : 6GJD   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Erk2 signalling protein
Release Data : 2019-01-02
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 1 A MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: MAPK1, ERK2, PRKM1, PRKM2
expression_system_strain: BL21
expression_system_variant: DE3
Authors : O'Reilly, M.
Keywords : Erk2, inhibitor, reversible probe, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.58 Å )
Citation :

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.

Lebraud, H.,Surova, O.,Courtin, A.  et al.
(2018)  Chem Sci  9 : 8608 - 8618

PubMed: 30568786
DOI: 10.1039/c8sc02754d

Reaction

Chain : A
UniProt : P28482 (MK01_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.24 PubMed:26942675
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.24 -
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000250
-