Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
F0K (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one
GCP Phosphomethylphosphonic acid guanylate ester
MG Magnesium ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 6GJ8   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852
Release Data : 2019-07-31
Compound :
mol_id molecule chains synonym
1 GTPase KRas A K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KRAS, KRAS2, RASK2
Authors : Kessler, D., Mcconnell, D.M., Mantoulidis, A.
Keywords : KRAS 4B, K-RAS 2, KI-RAS, C-K-RAS, C-KI-RAS, GTPASE KRAS, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Drugging an undruggable pocket on KRAS.

Kessler, D.,Gmachl, M.,Mantoulidis, A.  et al.
(2019)  Proc.Natl.Acad.Sci.USA  116 : 15823 - 15829

PubMed: 31332011
DOI: 10.1073/pnas.1904529116

Chain : A
UniProt : P01116 (RASK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate 3.6.5.2 PubMed:20949621
-