Brand  (β version)

PDB ID: 6G4L

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
F45 [6-(3,4-dihydroxyphenyl)pyridin-2-yl](4-fluoro-3-hydroxyphenyl)methanone PoSSuM
NA Sodium ion PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
BGC Beta-D-glucopyranose PoSSuM
Non-standard Residues
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Structure summary

Code : 6G4L   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : 17beta-hydroxysteroid Dehydrogenase Type 14 Mutant Y253A in Complex With a Non-steroidal Inhibitor
Release Data : 2019-04-10
Compound :
mol_id molecule chains synonym
1 17-beta-hydroxysteroid dehydrogenase 14 A 17-beta-HSD 14,17-beta-hydroxysteroid dehydrogenase DHRS10,Dehydrogenase/reductase SDR family member 10,Retinal short-chain dehydrogenase/reductase retSDR3,Short chain dehydrogenase/reductase family 47C member 1
ec: 1.1.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli 'BL21-Gold(DE3)pLysS AG'  (taxid:866768)
gene: HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474
Authors : Badran, M., Klebe, G., Heine, A., Marchais-Oberwinkler, S.
Keywords : Inhibitor Complex mutant, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.444 Å )
Citation :

Mutational and structural studies uncover crucial amino acids determining activity and stability of 17beta-HSD14

Badran, M.,Bertoletti, N.,Keils, A.  et al.
(2019)  J.Steroid Biochem.Mol.Biol. 

DOI: 10.1016/j.jsbmb.2019.02.009

Reaction

Chain : A
UniProt : Q9BPX1 (DHB14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
17beta-estradiol + NAD(+) = estrone + H(+) + NADH 1.1.1.62 PubMed:17067289
left-to-right
androst-5-en-3beta,17beta-diol + NAD(+) = 3beta- hydroxyandrost-5-en-17-one + H(+) + NADH - PubMed:17067289
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