Brand  (β version)

PDB ID: 6FTI

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Ligands
Code Name Style Show Link
9UB [(2~{S},3~{R},4~{R},5~{S},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]methyl-[oxidanyl-[(2~{z},6~{z},10~{z})-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy]phosphoryl]oxy-phosphinic acid PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 6FTI   PDBj   RCSB PDB   PDBe
Header : PROTEIN TRANSPORT
Title : Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome
Release Data : 2018-03-21
Compound :
mol_id molecule chains
1 uL2 A
mol_id molecule chains
2 uL3 B
mol_id molecule chains
3 Ribosomal protein L4 C
mol_id molecule chains
4 60S ribosomal protein L5 D
mol_id molecule chains
5 60S ribosomal protein L6 E
mol_id molecule chains
6 uL30 F
mol_id molecule chains
7 eL8 G
mol_id molecule chains
8 uL6 H
mol_id molecule chains
9 Ribosomal protein L10 (Predicted) I
mol_id molecule chains
10 Ribosomal protein L11 J
mol_id molecule chains
11 eL13 L
mol_id molecule chains
12 Ribosomal protein L14 M
mol_id molecule chains
13 Ribosomal protein L15 N
mol_id molecule chains
14 uL13 O
mol_id molecule chains
15 uL22 P
mol_id molecule chains
16 uL14 Q
mol_id molecule chains
17 eL19 R
mol_id molecule chains
18 eL20 S
mol_id molecule chains
19 eL21 T
mol_id molecule chains
20 eL22 U
mol_id molecule chains
21 uL14 V
mol_id molecule chains
22 Ribosomal protein L24 W
mol_id molecule chains
23 uL23 X
mol_id molecule chains
24 Ribosomal protein L26 Y
mol_id molecule chains
25 60S ribosomal protein L27 Z
mol_id molecule chains
26 uL15 a
mol_id molecule chains
27 60S ribosomal protein L29 b
mol_id molecule chains
28 eL30 c
mol_id molecule chains
29 eL31 d
mol_id molecule chains
30 eL32 e
mol_id molecule chains
31 eL33 f
mol_id molecule chains
32 eL34 g
mol_id molecule chains
33 uL29 h
mol_id molecule chains
34 60S ribosomal protein L36 i
mol_id molecule chains
35 Ribosomal protein L37 j
mol_id molecule chains
36 eL38 k
mol_id molecule chains
37 eL39 l
mol_id molecule chains
38 eL40 m
mol_id molecule chains
39 60s ribosomal protein l41 n
mol_id molecule chains
40 eL42 o
mol_id molecule chains
41 Ribosomal protein L37a p
mol_id molecule chains
42 eL28 r
mol_id molecule chains
43 60S acidic ribosomal protein P0 s
mol_id molecule chains
44 Ribosomal protein L12 t
mol_id molecule chains
45 p-Site tRNA q
mol_id molecule chains
46 28S rRNA u
mol_id molecule chains
47 5S ribosomal RNA v
mol_id molecule chains
48 5.8S ribosomal RNA w
mol_id molecule chains synonym
49 Protein transport protein Sec61 subunit alpha isoform 1 x Sec61 alpha-1
mol_id molecule chains
50 Protein transport protein Sec61 subunit gamma y
mol_id molecule chains
51 Protein transport protein Sec61 subunit beta z
mol_id molecule chains synonym
52 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1,RPN1 1 Ribophorin I,RPN-I,Ribophorin-1
mol_id molecule chains
53 TMEM258 2
mol_id molecule chains
54 Oligosaccharyltransferase complex subunit OSTC 3
mol_id molecule chains
55 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 4
mol_id molecule chains synonym
56 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 5 STT3-A
ec: 2.4.99.18
mol_id molecule chains
57 DAD1 6
mol_id molecule chains
58 OST48 7
mol_id molecule chains
59 RPN1 8
mol_id molecule chains
60 Unidentified TM 0
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
2 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
3 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
4 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
5 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
6 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
7 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
8 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
9 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
10 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
11 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
12 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
13 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
14 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
15 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
16 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
17 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
18 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
19 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
20 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
21 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
22 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
23 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
24 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
25 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
26 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
27 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
28 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
29 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
30 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
31 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
32 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
33 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
34 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
35 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
36 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
37 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
38 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
39 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
40 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
41 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
42 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
43 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
44 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
45 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
46 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
47 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
48 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
49 Canis lupus familiaris  (taxid:9615) Dog
tissue: pankreas
mol_id organism_scientific organism_common
50 Canis lupus familiaris  (taxid:9615) Dog
tissue: pankreas
mol_id organism_scientific organism_common
51 Canis lupus familiaris  (taxid:9615) Dog
tissue: pankreas
mol_id organism_scientific organism_common
52 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
53 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
54 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
55 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
56 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
57 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
58 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
59 Canis lupus familiaris  (taxid:9615) Dog
mol_id organism_scientific organism_common
60 Canis lupus familiaris  (taxid:9615) Dog
Authors : Braunger, K., Becker, T., Beckmann, R.
Keywords : Protein translocon of the endoplasmic reticulum, PROTEIN TRANSPORT
Exp. method : ELECTRON MICROSCOPY ( 4.2 Å )
Citation :

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum.

Braunger, K.,Pfeffer, S.,Shrimal, S.  et al.
(2018)  Science  360 : 215 - 219

PubMed: 29519914
DOI: 10.1126/science.aar7899

Reaction

Chain : A
UniProt : G1TT27 (RL8_RABIT)
Reaction : -
Chain : B
UniProt : G1TL06 (RL3_RABIT)
Reaction : -
Chain : C
UniProt : G1SVW5 (RL4_RABIT)
Reaction : -
Chain : D
UniProt : G1SYJ6 (RL5_RABIT)
Reaction : -
Chain : E
UniProt : G1TG04 (G1TG04_RABIT)
Reaction : -
Chain : F
UniProt : G1SV32 (RL7_RABIT)
Reaction : -
Chain : G
UniProt : G1STW0 (RL7A_RABIT)
Reaction : -
Chain : H
UniProt : G1TX33 (RL9_RABIT)
Reaction : -
Chain : I
UniProt : B7NZQ2 (RL10_RABIT)
Reaction : -
Chain : J
UniProt : G1TUB8 (RL11_RABIT)
Reaction : -
Chain : M
UniProt : U3KNW6 (RL14_RABIT)
Reaction : -
Chain : N
UniProt : G1T0C1 (RL15_RABIT)
Reaction : -
Chain : P
UniProt : G1TVT6 (RL17_RABIT)
Reaction : -
Chain : T
UniProt : G1SHQ2 (RL21_RABIT)
Reaction : -
Chain : V
UniProt : G1T6D1 (RL23_RABIT)
Reaction : -
Chain : W
UniProt : G1SE28 (RL24_RABIT)
Reaction : -
Chain : X
UniProt : G1SE76 (RL23A_RABIT)
Reaction : -
Chain : Y
UniProt : G1SQH0 (RL26_RABIT)
Reaction : -
Chain : Z
UniProt : G1TXF6 (RL27_RABIT)
Reaction : -
Chain : a
UniProt : G1SNY0 (RL27A_RABIT)
Reaction : -
Chain : b
UniProt : G1TN82 (RL29_RABIT)
Reaction : -
Chain : d
UniProt : G1SHG0 (RL31_RABIT)
Reaction : -
Chain : e
UniProt : G1TUN8 (RL32_RABIT)
Reaction : -
Chain : f
UniProt : G1SF08 (RL35A_RABIT)
Reaction : -
Chain : g
UniProt : G1U945 (RL34_RABIT)
Reaction : -
Chain : h
UniProt : G1SIT5 (RL35_RABIT)
Reaction : -
Chain : i
UniProt : G1TTQ5 (RL36_RABIT)
Reaction : -
Chain : j
UniProt : U3KPD5 (RL37_RABIT)
Reaction : -
Chain : l
UniProt : G1SYU7 (RL39_RABIT)
Reaction : -
Chain : n
UniProt : A0A087WNH4 (RS32_RABIT)
Reaction : -
Chain : o
UniProt : G1T040 (RL36A_RABIT)
Reaction : -
Chain : p
UniProt : G1SY53 (RL37A_RABIT)
Reaction : -
Chain : r
UniProt : G1U7L1 (RL28_RABIT)
Reaction : -
Chain : s
UniProt : G1U6N2
Reaction : -
Chain : t
UniProt : G1SMR7 (RL12_RABIT)
Reaction : -
Chain : x
UniProt : P38377 (S61A1_CANLF)
Reaction : -
Chain : y
UniProt : P60058 (SC61G_CANLF)
Reaction : -
Chain : z
UniProt : P60467 (SC61B_CANLF)
Reaction : -
Chain : 1
UniProt : E2RQ08 (RPN1_CANLF)
Reaction : -
Chain : 3
UniProt : P86218 (OSTC_CANLF)
Reaction : -
Chain : 5
UniProt : F1PJP5 (STT3A_CANLF)
Reaction: EC: Evidence:
Physiological Direction:
a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L- asparaginyl-[protein] = N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D- glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl- [protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+) 2.4.99.18 UniProtKB:P39007
-
Cofactor: Evidence: Note:
Mn(2+) ECO:0000250 | UniProtKB:P46977
ECO:0000250 | UniProtKB:B9KDD4
-