Brand  (β version)

PDB ID: 6FSO

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
F63 N-methyl-1-[5-(pyridin-3-yloxy)furan-2-yl]methanamine PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PG4 Tetraethylene glycol PoSSuM
PGE Triethylene glycol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 6FSO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of TGT in complex with methyl({[5-(pyridin-3-yloxy)furan-2-yl]methyl})amine
Release Data : 2019-03-20
Compound :
mol_id molecule chains synonym
1 Queuine tRNA-ribosyltransferase A Guanine insertion enzyme,tRNA-guanine transglycosylase
ec: 2.4.2.29
Source :
mol_id organism_scientific expression_system
1 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)  (taxid:264203) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 31821 / ZM4 / CP4
gene: tgt, ZMO0363
Authors : Hassaan, E., Heine, A., Klebe, G.
Keywords : TGT, TRNA, GUANINE EXCHANGE ENZYME, PROTEIN INTERFACE, transferase
Exp. method : X-RAY DIFFRACTION ( 1.449 Å )
Citation :

Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies.

Hassaan, E.,Eriksson, P.O.,Geschwindner, S.  et al.
(2020)  Chemmedchem  15 : 324 - 337

PubMed: 31808981
DOI: 10.1002/cmdc.201900604

Reaction

Chain : A
UniProt : P28720 (TGT_ZYMMO)
Reaction: EC: Evidence:
Physiological Direction:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine 2.4.2.29 HAMAP-Rule:MF_00168, PubMed:7665516
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000255 | HAMAP-Rule:MF_00168
ECO:0000269 | PubMed:10413112
ECO:0000269 | PubMed:11178905
ECO:0000269 | PubMed:11921407
ECO:0000269 | PubMed:12646024
ECO:0000269 | PubMed:12909636
ECO:0000269 | PubMed:12949492
ECO:0000269 | PubMed:14523925
ECO:0000269 | PubMed:19627989
ECO:0000269 | PubMed:8654383
ECO:0000269 | PubMed:8961936
Binds 1 zinc ion per subunit.