Het-PDB Navi2 (PDB: 6F7I)

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Ligands
Code	Name	Link
CW5	1-[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloranyl-6-pyrrolidin-1-ylcarbonyl-pyridin-3-yl)urea	PoSSuM
GOL	Glycerol	PoSSuM
MG	Magnesium ion	PoSSuM

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Download interaction data: 6F7I

Code :

6F7I PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

human MALT1(329-728) IN COMPLEX WITH MLT-747

Release Data :

2019-01-02

Compound :

mol_id	molecule	chains	synonym
1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	A,B	MALT lymphoma-associated translocation,Paracaspase
	ec: 3.4.22.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: MALT1, MLT expression_system_vector_type: plasmid expression_system_vector: pET28a

Authors :

Renatus, M., Renatus, M.

Keywords :

DIMER, EXOSITE BINDER, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.43 Å )

Citation :

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Quancard, J.,Klein, T.,Fung, S.Y. et al.
(2019) Nat. Chem. Biol. 15 : 304 - 313

PDB ID: 6F7I