Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CW5 1-[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloranyl-6-pyrrolidin-1-ylcarbonyl-pyridin-3-yl)urea
GOL Glycerol
MG Magnesium ion
Code : 6F7I
Header : HYDROLASE
Title : human MALT1(329-728) IN COMPLEX WITH MLT-747
Release Data : 2019-01-02
Compound :
mol_id molecule chains synonym
1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 A,B MALT lymphoma-associated translocation,Paracaspase
ec: 3.4.22.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MALT1, MLT
expression_system_vector_type: plasmid
expression_system_vector: pET28a
Authors : Renatus, M., Renatus, M.
Keywords : DIMER, EXOSITE BINDER, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.43 Å )
Citation :

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Quancard, J.,Klein, T.,Fung, S.Y.  et al.
(2019)  Nat. Chem. Biol.  15 : 304 - 313

PubMed: 30692685
DOI: 10.1038/s41589-018-0222-1

Chain : A, B
UniProt : Q9UDY8 (MALT1_HUMAN)
Reaction : -