Brand  (β version)

PDB ID: 6F7C

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Ligands
Code Name Style Show Link
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
CA Calcium ion PoSSuM
CVT 3,4,5-trimethoxy-~{N}-[(~{E})-naphthalen-1-ylmethylideneamino]benzamide PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6F7C   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : TUBULIN-Compound 12 complex
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3,RB3
mol_id molecule chains
4 Tubulin tyrosine ligase F
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
organ: Brain
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine
organ: Brain
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
gene: TTL
Authors : Muehlethaler, T., Prota, A.E., Steinmetz, M.O.
Keywords : CELL CYCLE, TUBULIN FOLD, CYTOSKELETON, MICROTUBULE
Exp. method : X-RAY DIFFRACTION ( 2.002 Å )
Citation :

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.

Cury, N.M.,Muhlethaler, T.,Laranjeira, A.B.A.  et al.
(2019)  Iscience  21 : 95 - 109

PubMed: 31655259
DOI: 10.1016/j.isci.2019.10.003

Reaction

Chain : A, C
UniProt : P81947 (TBA1B_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P68363
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -