Brand  (β version)

PDB ID: 6F7B

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Ligands
Code Name Style Show Link
CVQ 2-[3,5-bis(fluoranyl)-4-[[3-[5-methoxy-4-[(3-methoxypyridin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol PoSSuM
MG Magnesium ion PoSSuM
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SEP Phosphoserine
Glycosylation
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Structure summary

Code : 6F7B   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Mitotic checkpoint serine/threonine-protein kinase BUB1 A hBUB1,BUB1A
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: BUB1, BUB1L
Authors : Holton, S.J., Siemeister, G., Mengel, A., Bone, W., Schroeder, J., Zitzmann-Kolbe, S., Briem, H., Fernandez-Montalvan, A., Prechtl, S., Moenning, U., von Ahsen, O., Johanssen, J., Cleve, A., Puetter, V., Hitchcock, M., von Nussbaum, F., Brands, M., Mumberg, D., Ziegelbauer, K.
Keywords : BUB1, kinase inhibitor, transferase
Exp. method : X-RAY DIFFRACTION ( 2 Å )
Citation :

Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo.

Siemeister, G.,Mengel, A.,Fernandez-Montalvan, A.E.  et al.
(2019)  Clin.Cancer Res.  25 : 1404 - 1414

PubMed: 30429199
DOI: 10.1158/1078-0432.CCR-18-0628

Reaction

Chain : A
UniProt : O43683 (BUB1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-