Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CVK 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline
GNP Phosphoaminophosphonic acid-guanylate ester
MG Magnesium ion
Code : 6F76
Header : ONCOPROTEIN
Title : Antibody derived (Abd-8) small molecule binding to KRAS.
Release Data : 2018-08-08
Compound :
mol_id molecule chains synonym
1 GTPase KRas B,A,C,D,E,F K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
mutation: Q61H
other_details: KRAS169 Q61H GppNHp
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KRAS, KRAS2, RASK2
Authors : Bery, N., Cruz-Migoni, A., Quevedo, C.E., Phillips, S.V.E., Carr, S., Rabbitts, T.H.
Keywords : Abd-8, inhibitor, KRAS, ONCOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.

Bery, N.,Cruz-Migoni, A.,Bataille, C.J.  et al.
(2018)  Elife  7

PubMed: 29989546
DOI: 10.7554/eLife.37122

Chain : B, A, C, D, E, F
UniProt : P01116 (RASK_HUMAN)
Reaction : -