Het-PDB Navi2 (PDB: 6F76)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
CVK	4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline	PoSSuM
GNP	Phosphoaminophosphonic acid-guanylate ester	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6F76

Code :

6F76 PDBj RCSB PDB PDBe

Header :

ONCOPROTEIN

Title :

Antibody derived (Abd-8) small molecule binding to KRAS.

Release Data :

2018-08-08

Compound :

mol_id	molecule	chains	synonym
1	GTPase KRas	B,A,C,D,E,F	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
	mutation: Q61H other_details: KRAS169 Q61H GppNHp

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: KRAS, KRAS2, RASK2

Authors :

Bery, N., Cruz-Migoni, A., Quevedo, C.E., Phillips, S.V.E., Carr, S., Rabbitts, T.H.

Keywords :

Abd-8, inhibitor, KRAS, ONCOPROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.

Bery, N.,Cruz-Migoni, A.,Bataille, C.J. et al.
(2018) Elife 7

Chain :

B, A, C, D, E, F

UniProt :

P01116 (RASK_HUMAN)

PDB ID: 6F76