Brand  (β version)

PDB ID: 6F6T

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Ligands
Code Name Style Show Link
CV2 (S)-(1-amino-2phenylallyl)phosphonic acid PoSSuM
Non-standard Residues
Code Name Show
MDO {2-[(1s)-1-aminoethyl]-4-methylidene-5-oxo-4,5-dihydro-1h-imidazol-1-yl}acetic acid
Glycosylation
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Structure summary

Code : 6F6T   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Phenylalanine ammonia-lyase (PAL) from Petroselinum crispum complexed with S-APPA
Release Data : 2019-06-26
Compound :
mol_id molecule chains
1 Phenylalanine ammonia-lyase 1 A,B
ec: 4.3.1.24
mutation: A202X, S203X, G204X, C704S, C716S
Source :
mol_id organism_scientific organism_common expression_system
1 Petroselinum crispum  (taxid:4043) Parsley Escherichia coli  (taxid:562)
gene: PAL1
expression_system_variant: Rosetta
expression_system_vector_type: pET19-B
Authors : Bata, Z., Leveles, I., Vertessy, G.B., Poppe, L.
Keywords : Inhibitor, Complex, Phenylalanine ammonia-lyase, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.89995964358 Å )
Citation :

Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes

Bata, Z.,Molnar, Z.,Madaras, E.  et al.
(2021)  Acs Catalysis  : 4538 - 4549

DOI: 10.1021/acscatal.1c00266

A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases.

Bata, Z.,Qian, R.,Roller, A.  et al.
(2017)  Adv. Synth. Catal.  359 : 2109 - 2120

PubMed: 28919846
DOI: 10.1002/adsc.201700428

EXPRESSION AND PURIFICATION OF RECOMBINANT PHENYLALANINE AMMONIA-LYASE FROM PETROSELINUM CRISPUM

Bata, Z.
(2016)  STUDIA UBB CHEMIA,  LXI : 21 - 34

Reaction

Chain : A, B
UniProt : P24481 (PAL1_PETCR)
Reaction: EC: Evidence:
Physiological Direction:
L-phenylalanine = (E)-cinnamate + NH4(+) 4.3.1.24 PubMed:15548745, PubMed:8050576
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