Brand  (β version)

PDB ID: 6F6S

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Ligands
Code Name Style Show Link
CXQ Benztropine PoSSuM
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6F6S   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH benztropine
Release Data : 2018-01-03
Compound :
mol_id molecule chains synonym
1 Envelope glycoprotein,Envelope glycoprotein,GP1 A GP1,2,GP,GP1,2,GP
other_details: mutation T42A,mutation T42A,mutation T42A
mol_id molecule chains
2 Envelope glycoprotein B
other_details: mutation, H613A
Source :
mol_id organism_scientific organism_common expression_system
1 Ebola virus  (taxid:1570291) ZEBOV Homo sapiens  (taxid:9606)
strain: Mayinga-76
gene: GP
expression_system_cell_line: HEK293T
mol_id organism_scientific expression_system
2 Ebola virus  (taxid:1570291) Homo sapiens  (taxid:9606)
gene: GP, DF49_53415gpGP, DF49_53416gpGP, DF49_53417gpGP, DF49_53418gpGP, DF49_53419gpGP, DF49_53420gpGP, DF49_53421gpGP, DF49_53422gpGP, DF49_53423gpGP, DF49_53424gpGP, DF49_53425gpGP, DF49_53426gpGP
expression_system_cell_line: HEK293T
Authors : Ren, J., Zhao, Y., Fry, E.E., Stuart, D.I.
Keywords : EBOLA VIRUS, FILOVIRIDAE, ENVELOPE GLYCOPROTEIN, PROTEIN INHIBITOR COMPLEX, IBUPROFEN, benztropine, bepridil, paroxetine, sertraline, TOREMIFENE, VIRAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.290 Å )
Citation :

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection.

Ren, J.,Zhao, Y.,Fry, E.E.  et al.
(2018)  J. Med. Chem.  61 : 724 - 733

PubMed: 29272110
DOI: 10.1021/acs.jmedchem.7b01249

Toremifene interacts with and destabilizes the Ebola virus glycoprotein.

Zhao, Y.,Ren, J.,Harlos, K.  et al.
(2016)  Nature  535 : 169 - 172

PubMed: 27362232
DOI: 10.1038/nature18615

Reaction

Chain : A
UniProt : Q05320 (VGP_EBOZM)
Reaction : -
Chain : B
UniProt : A0A0U3BWW0 (A0A0U3BWW0_9MONO)
Reaction : -