Brand  (β version)

PDB ID: 6F6J

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Ligands
Code Name Style Show Link
FE Fe (III) ion PoSSuM
SIN Succinic acid PoSSuM
CUW (2~{S},3~{R})-2,6-bis(azanyl)-3-oxidanyl-hexanoic acid PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6F6J   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of the Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO1 with Fe(II)/succinate/(3S)-3-hydroxy-L-lysine
Release Data : 2018-11-14
Compound :
mol_id molecule chains synonym
1 L-lysine 3-hydroxylase A,B,C,D Alpha-ketoglutarate-dependent dioxygenase,KDO1,L-lysine hydroxylase
ec: 1.14.11.-
Source :
mol_id organism_scientific expression_system
1 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)  (taxid:479433) Escherichia coli  (taxid:562)
strain: DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897
gene: Caci_0231
Authors : Isabet, T., Stura, E.A., Legrand, P., Zaparucha, A., Bastard, K.
Keywords : Fe(II)/alpha-ketoglutarate, dioxygenases, enzyme, FeII alphaKG form, oxydoreductase, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.

Bastard, K.,Isabet, T.,Stura, E.A.  et al.
(2018)  Sci Rep  8 : 16587 - 16587

PubMed: 30410048
DOI: 10.1038/s41598-018-34795-9

Reaction

Chain : A, B, C, D
UniProt : C7QJ42 (LYS3O_CATAD)
Reaction: EC: Evidence:
Physiological Direction:
L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-lysine + succinate + CO2 - Ref.2
-
Cofactor: Evidence: Note:
Fe(2+) ECO:0000250 | UniProtKB:Q9Z4Z5
Binds 1 Fe(2+) ion per subunit.