Brand  (β version)

PDB ID: 6F5H

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Ligands
Code Name Style Show Link
CQ5 3-[[4-oxidanyl-1-[(3~{R})-3-phenylbutanoyl]piperidin-4-yl]methyl]-6-(2-pyrrolidin-1-ylethylamino)pyrimidin-4-one PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6F5H   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of USP7 in complex with a 4-hydroxypiperidine based inhibitor
Release Data : 2018-04-11
Compound :
mol_id molecule chains synonym
1 Ubiquitin carboxyl-terminal hydrolase 7 A,B Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7
ec: 3.4.19.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: USP7, HAUSP
Authors : Harrison, T., Gavory, G., O'Dowd, C., Helm, M., Flasz, J., Dossang, A., Hughes, C., Cassidy, E., McClelland, K., Odrzywol, E., Page, N., Barker, O., Miel, H., Feutron-Burton, S., Rountree, J.S.S.
Keywords : USP7, reversible, inhibitor, selective, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.1600 Å )
Citation :

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.

O'Dowd, C.R.,Helm, M.D.,Rountree, J.S.S.  et al.
(2018)  ACS Med Chem Lett  9 : 238 - 243

PubMed: 29541367
DOI: 10.1021/acsmedchemlett.7b00512

Reaction

Chain : A, B
UniProt : Q93009 (UBP7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal). 3.4.19.12 PubMed:11923872, PubMed:12507430, PubMed:14506283, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:21745816, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:35216969
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