Brand  (β version)

PDB ID: 6F3U

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Ligands
Code Name Style Show Link
CNK (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(5-naphthalen-1-yl-4~{H}-1,2,4-triazol-3-yl)oxane-3,4,5-triol PoSSuM
IMP Inosinic acid PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6F3U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The crystal structure of Glycogen Phosphorylase in complex with 10h
Release Data : 2018-02-28
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: muscle
Authors : Kyriakis, E., Gkerdi, A., Stravodimos, G.A., Skamnaki, V.T., Leonidas, D.D.
Keywords : Transferase
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.

Kun, S.,Begum, J.,Kyriakis, E.  et al.
(2018)  Eur J Med Chem  147 : 266 - 278

PubMed: 29453094
DOI: 10.1016/j.ejmech.2018.01.095

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
left-to-right
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:7500360
ECO:0000269 | PubMed:8976550
ECO:0007744 | PDB:2PRI
ECO:0007744 | PDB:2SKC
ECO:0007744 | PDB:2SKD
ECO:0007744 | PDB:2SKE
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