Het-PDB Navi2 (PDB: 6F3E)

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Ligands
Code	Name		Style	Show	Link
SO4	Sulfate ion				PoSSuM
CJQ	2-[(3~{R})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide				PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 6F3E

Code :

6F3E PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

IRAK4 IN COMPLEX WITH inhibitor

Release Data :

2018-05-23

Compound :

mol_id	molecule	chains	synonym
1	Interleukin-1 receptor-associated kinase 4	A,B	IRAK-4,Renal carcinoma antigen NY-REN-64
	ec: 2.7.11.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: IRAK4 expression_system_common: Fall armyworm

Authors :

Xue, Y., Degorce, S.L., Robb, G.R., Ferguson, A.D.

Keywords :

IRAK4, kinase, inhibitor, cancer, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.67 Å )

Citation :

Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.

Degorce, S.L.,Anjum, R.,Dillman, K.S. et al.
(2018) Bioorg. Med. Chem. 26 : 913 - 924

Chain :

A, B

UniProt :

Q9NWZ3 (IRAK4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	-
	-	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	-
	-	-
Cofactor:	Evidence:	Note:
Mg(2+)	-	-

PDB ID: 6F3E