Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CJQ 2-[(3~{R})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide
SO4 Sulfate ion
Modified Residues
Code Name Link
TPO Phosphothreonine
Code : 6F3E
Header : SIGNALING PROTEIN
Title : IRAK4 IN COMPLEX WITH inhibitor
Release Data : 2018-05-23
Compound :
mol_id molecule chains synonym
1 Interleukin-1 receptor-associated kinase 4 A,B IRAK-4,Renal carcinoma antigen NY-REN-64
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: IRAK4
expression_system_common: Fall armyworm
Authors : Xue, Y., Degorce, S.L., Robb, G.R., Ferguson, A.D.
Keywords : IRAK4, kinase, inhibitor, cancer, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.67 Å )
Citation :

Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.

Degorce, S.L.,Anjum, R.,Dillman, K.S.  et al.
(2018)  Bioorg. Med. Chem.  26 : 913 - 924

PubMed: 29398441
DOI: 10.1016/j.bmc.2018.01.008

Chain : A, B
UniProt : Q9NWZ3 (IRAK4_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.