Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CF8 (~{z})-3-[2-(naphthalen-2-ylmethyl)phenyl]-2-sulfanyl-prop-2-enoic acid
SO4 Sulfate ion
ZN Zinc ion
Code : 6F2N
Header : HYDROLASE
Title : Crystal structure of BCII Metallo-beta-lactamase in complex with KDU197
Release Data : 2018-10-03
Compound :
mol_id molecule chains synonym
1 Metallo-beta-lactamase type 2 A B2 metallo-beta-lactamase,Beta-lactamase II,Cephalosporinase,Metallo-beta-lactamase type II,Metallothioprotein beta-lactamase II,Penicillinase,Zinc-requiring beta-lactamase II
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Bacillus cereus  (taxid:1396) Escherichia coli 'BL21-Gold(DE3)pLysS AG'  (taxid:866768)
gene: blm
expression_system_vector_type: plasmid
expression_system_plasmid: PET9A
Authors : McDonough, M.A., El-Hussein, A., Schofield, C.J., Zhang, D., Brem, J.
Keywords : ANTIMICROBIAL RESISTANCE, METALLO BETA LACTAMASE, INHIBITOR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.1490 Å )
Citation :

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.

Zhang, D.,Markoulides, M.S.,Stepanovs, D.  et al.
(2018)  Bioorg. Med. Chem.  26 : 2928 - 2936

PubMed: 29655609
DOI: 10.1016/j.bmc.2018.02.043

Chain : A
UniProt : P04190 (BLA2_BACCE)
Reaction : A beta-lactam + H(2)O = a substituted beta- amino acid.