Brand  (β version)

PDB ID: 6F29

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Ligands
Code Name Style Show Link
CGW (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-D]pyrimidin-1-yl]propanoic acid PoSSuM
CL Chloride ion PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6F29   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-D]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A
Release Data : 2018-02-28
Compound :
mol_id molecule chains synonym
1 Glutamate receptor ionotropic, kainate 3,Glutamate receptor ionotropic, kainate 3 A GluK3,Glutamate receptor 7,GluR7,GluK3,Glutamate receptor 7,GluR7
other_details: THE PROTEIN CRYSTALLIZED IS THE EXTRACELLULAR LIGAND BINDING DOMAIN OF GLUK3. TRANSMEMBRANE REGIONS WERE GENETICALLY REMOVED AND REPLACED WITH A GLY-THR LINKER (RESIDUES 119 AND 120 OF THE STRUCTURE). THEREFORE, THE SEQUENCE MATCHES DISCONTINUOUSLY WITH THE REFERENCE DATABASE (432-546, 669-806)
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Grik3, Glur7
expression_system_strain: Origami 2
expression_system_vector_type: Plasmid
expression_system_plasmid: POPINJ
Authors : Venskutonyte, R., Frydenvang, K., Kastrup, J.S.
Keywords : ionotropic glutamate receptor, GluK3, ligand binding domain, membrane protein., MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.6000 Å )
Citation :

( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.

Brogi, S.,Brindisi, M.,Butini, S.  et al.
(2018)  J. Med. Chem.  61 : 2124 - 2130

PubMed: 29451794
DOI: 10.1021/acs.jmedchem.8b00099

Reaction

Chain : A
UniProt : P42264 (GRIK3_RAT)
Reaction : -