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Ligands
Code Name Style Show Link
CL Chloride ion
CVZ 3-[(~{E})-5-[ethyl-[(2-nitrophenyl)methyl]amino]pent-1-enyl]-1-[5-[ethyl-[(2-nitrophenyl)methyl]amino]pentyl]-6-methyl-pyrimidine-2,4-dione
SO4 Sulfate ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 6F25   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of human acetylcholinesterase in complex with C35.
Release Data : 2018-12-12
Compound :
mol_id molecule chains synonym
1 Acetylcholinesterase A,B AChE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: ACHE
Authors : Dias, J., Nachon, F.
Keywords : Acetylcholinesterase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 3.05199647812 Å )
Citation :

New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease.

Zueva, I.,Dias, J.,Lushchekina, S.  et al.
(2019)  Neuropharmacology  155 : 131 - 141

PubMed: 31132435
DOI: 10.1016/j.neuropharm.2019.05.025

Chain : A, B
UniProt : P22303 (ACES_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 PubMed:1517212
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