Brand  (β version)

PDB ID: 6F0E

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Ligands
Code Name Style Show Link
C8K ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6F0E   PDBj   RCSB PDB   PDBe
Header : LIPID BINDING PROTEIN
Title : Structure of yeast Sec14p with a picolinamide compound
Release Data : 2018-01-17
Compound :
mol_id molecule chains synonym
1 SEC14 cytosolic factor A Phosphatidylinositol/phosphatidylcholine transfer protein,PI/PC TP
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast Escherichia coli  (taxid:562)
strain: ATCC 204508 / S288c
gene: SEC14, PIT1, YMR079W, YM9582.04
Authors : Hong, Z., Johnen, P., Schaaf, G., Bono, F.
Keywords : Sec14p, lipid transfer protein, chemogenomics, target identification, functional variomics, co-crystal, antifungal, benzamide, picolinamide, lipid binding protein
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

Pries, V.,Nocker, C.,Khan, D.  et al.
(2018)  Cell Chem Biol  25 : 279 - 290.e7

PubMed: 29307839
DOI: 10.1016/j.chembiol.2017.12.007

Reaction

Chain : A
UniProt : P24280 (SEC14_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) - PubMed:10848624
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a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl- sn-glycero-3-phosphocholine(out) - PubMed:10848624
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