PDB ID: 6F06
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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C7T | (3~{S},14~{E})-8-(azetidin-3-yl)-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide | PoSSuM | |||
ZN | Zinc ion | PoSSuM | |||
CL | Chloride ion | PoSSuM |
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Download interaction data: 6F06
Structure summary
Code : | 6F06 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide | ||||||||||||
Release Data : | 2018-04-11 | ||||||||||||
Compound : |
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Authors : | Kuglstatter, A., Stihle, M. | ||||||||||||
Keywords : | PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.02 Å ) | ||||||||||||
Citation : |
Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
Giroud, M.,Dietzel, U.,Anselm, L.
et al.
PubMed: 29590750 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P07711 (CATL1_HUMAN) | ||||||||
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