Brand  (β version)

PDB ID: 6F06

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Ligands
Code Name Style Show Link
C7T (3~{S},14~{E})-8-(azetidin-3-yl)-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide PoSSuM
ZN Zinc ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6F06   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide
Release Data : 2018-04-11
Compound :
mol_id molecule chains synonym
1 Cathepsin L1 A,B Cathepsin L,Major excreted protein,MEP
ec: 3.4.22.15
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CTSL, CTSL1
Authors : Kuglstatter, A., Stihle, M.
Keywords : PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.02 Å )
Citation :

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud, M.,Dietzel, U.,Anselm, L.  et al.
(2018)  J. Med. Chem.  61 : 3350 - 3369

PubMed: 29590750
DOI: 10.1021/acs.jmedchem.7b01869

Reaction

Chain : A, B
UniProt : P07711 (CATL1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl- dipeptidase activity. 3.4.22.15 PubMed:37990007, PubMed:9468501
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