Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
C3T (3~{S},6~{S},7~{S},9~{a}~{S})-~{N}-[(4-~{tert}-butylphenyl)methyl]-7-(hydroxymethyl)-6-[[(2~{S})-2-(methylamino)butanoyl]amino]-5-oxidanylidene-1,2,3,6,7,8,9,9~{a}-octahydropyrrolo[1,2-a]azepine-3-carboxamide
ZN Zinc ion
Code : 6EY2
Header : SIGNALING PROTEIN
Title : Crystal structure of XIAP-BIR3 in complex with a cIAP1-selective SM
Release Data : 2018-08-08
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase XIAP A,B,C,D,E,F,G,H Baculoviral IAP repeat-containing protein 4,IAP-like protein,hILP,Inhibitor of apoptosis protein 3,hIAP3,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein,X-linked IAP
ec: 2.3.2.27
fragment: Zinc-finger protein
mutation: none
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: XIAP, API3, BIRC4, IAP3
expression_system_vector_type: plasmid
expression_system_plasmid: pET28b
Authors : Cossu, F., Corti, A., Milani, M., Mastrangelo, E.
Keywords : Zinc finger motif, smac-mimetic, protein-ligand complex, BIR domain, signaling protein
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.

Corti, A.,Milani, M.,Lecis, D.  et al.
(2018)  FEBS J.  285 : 3286 - 3298

PubMed: 30055105
DOI: 10.1111/febs.14616

Chain : A, B, C, D, E, F, G, H
UniProt : P98170 (XIAP_HUMAN)
Reaction : S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin- conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.