Het-PDB Navi2 (PDB: 6EXK)

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Ligands
Code	Name	Link
C2Q	[(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium	PoSSuM
IPA	Isopropyl alcohol	PoSSuM
NA	Sodium ion	PoSSuM

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Download interaction data: 6EXK

Code :

6EXK PDBj RCSB PDB PDBe

Header :

DNA BINDING PROTEIN

Title :

The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (MK206) - unfolded HTH motif

Release Data :

2018-05-02

Compound :

mol_id	molecule	chains
1	Listeriolysin regulatory protein	A,B

Source :

mol_id	organism_scientific	expression_system
1	Listeria monocytogenes EGD-e (taxid:169963)	Escherichia coli (taxid:562)
	strain: ATCC BAA-679 / EGD-e gene: prfA, lmo0200

Authors :

Hall, M., Grundstrom, C., Begum, A., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.

Keywords :

Transcription regulator, DNA binding, 2-pyridone, drug design, Listeria monocytogenes, DNA BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.

Kulen, M.,Lindgren, M.,Hansen, S. et al.
(2018) J. Med. Chem. 61 : 4165 - 4175

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

Good, J.A.,Andersson, C.,Hansen, S. et al.
(2016) Cell Chem Biol 23 : 404 - 414

PDB ID: 6EXK