Brand  (β version)

PDB ID: 6EWE

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
C0W (~{z})-3-(1-benzothiophen-3-yl)-2-sulfanyl-prop-2-enoic acid PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6EWE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of BCII Metallo-beta-lactamase in complex with DZ-308
Release Data : 2018-10-03
Compound :
mol_id molecule chains synonym
1 Metallo-beta-lactamase type 2 A B2 metallo-beta-lactamase,Beta-lactamase II,Cephalosporinase,Metallo-beta-lactamase type II,Metallothioprotein beta-lactamase II,Penicillinase,Zinc-requiring beta-lactamase II
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Bacillus cereus  (taxid:1396) Escherichia coli  (taxid:562)
gene: blm
Authors : Stepanovs, D., McDonough, M.A., Schofield, C.J., Zhang, D., El-Husseiny, A., Brem, J.
Keywords : ANTIMICROBIAL RESISTANCE, METALLO BETA LACTAMASE, INHIBITOR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.4600 Å )
Citation :

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.

Zhang, D.,Markoulides, M.S.,Stepanovs, D.  et al.
(2018)  Bioorg. Med. Chem.  26 : 2928 - 2936

PubMed: 29655609
DOI: 10.1016/j.bmc.2018.02.043

Reaction

Chain : A
UniProt : P04190 (BLA2_BACCE)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 UniProtKB:P25910
-