Brand  (β version)

PDB ID: 6EQX

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
00S 4-(aminomethyl)benzenecarboximidamide

Structure summary

Code : 6EQX   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba
Release Data : 2018-02-28
Compound :
mol_id molecule chains synonym
1 Furin A Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
ec: 3.4.21.75
mol_id molecule chains
2 Arg-Arg-Arg-Val-Arg-00S D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: FURIN, FUR, PACE, PCSK3
expression_system_cell_line: HEK293S
mol_id organism_scientific expression_system
2 Synthetic construct  (taxid:32630) Synthetic construct  (taxid:32630)
Authors : Dahms, S.O., Than, M.E.
Keywords : protease, inhibitor, proprotein convertase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.994 Å )
Citation :

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.

Dahms, S.O.,Hardes, K.,Steinmetzer, T.  et al.
(2018)  Biochemistry  57 : 925 - 934

PubMed: 29314830
DOI: 10.1021/acs.biochem.7b01124

Reaction

Chain : A
UniProt : P09958 (FURIN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. 3.4.21.75 PubMed:11799113, PubMed:1438214, PubMed:1629222, PubMed:1644824, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:31091448, PubMed:32362314, PubMed:32703818, PubMed:7592877, PubMed:7690548, PubMed:7737999, PubMed:8253774, PubMed:9130696
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:1644824
ECO:0000269 | PubMed:24666235
ECO:0000269 | PubMed:25974265
ECO:0000269 | PubMed:9130696
Binds 3 calcium ions per subunit.