Brand  (β version)

PDB ID: 6EOP

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Ligands
Code Name Style Show Link
FLC Citrate anion PoSSuM
CA Calcium ion PoSSuM
F15 Pentadecanoic acid PoSSuM
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Modification
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Structure summary

Code : 6EOP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : DPP8 - SLRFLYEG, space group 20
Release Data : 2018-02-07
Compound :
mol_id molecule chains synonym
1 Dipeptidyl peptidase 8 A,B,C DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8
ec: 3.4.14.5
mol_id molecule chains
2 SER-LEU-ARG-PHE-LEU-TYR-GLU-GLY D,E,F
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
Authors : Ross, B.R., Huber, R.
Keywords : DPP8, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.

Ross, B.,Krapp, S.,Augustin, M.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : E1437 - E1445

PubMed: 29382749
DOI: 10.1073/pnas.1717565115

Reaction

Chain : A, B, C
UniProt : Q6V1X1 (DPP8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749
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