Brand  (β version)

PDB ID: 6EEM

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Ligands
Code Name Style Show Link
0PR N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-tyrosine PoSSuM
SO4 Sulfate ion PoSSuM
TYR Tyrosine PoSSuM
Non-standard Residues
Code Name Show
LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
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Modification
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Structure summary

Code : 6EEM   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of Papaver somniferum tyrosine decarboxylase in complex with L-tyrosine
Release Data : 2018-09-19
Compound :
mol_id molecule chains
1 Tyrosine/dopa decarboxylase A
ec: 4.1.1.28
mol_id molecule chains
2 Tyrosine/dopa decarboxylase B
ec: 4.1.1.28
Source :
mol_id organism_scientific organism_common expression_system
1 Papaver somniferum  (taxid:3469) Opium poppy Escherichia coli  (taxid:562)
gene: tydc9
mol_id organism_scientific organism_common expression_system
2 Papaver somniferum  (taxid:3469) Opium poppy Escherichia coli  (taxid:562)
gene: tydc9
Authors : Torrens-Spence, M.P., Chiang, Y., Smith, T., Vicent, M.A., Wang, Y., Weng, J.K.
Keywords : Aromatic Amino Acid Decarboxylase, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.61000662305 Å )
Citation :

Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins.

Torrens-Spence, M.P.,Chiang, Y.C.,Smith, T.  et al.
(2020)  Proc.Natl.Acad.Sci.USA  117 : 10806 - 10817

PubMed: 32371491
DOI: 10.1073/pnas.1920097117

Structural basis for independent origins of new catalytic machineries in plant AAAD proteins

Torrens-Spence, M.P.,Chiang, Y.-C.,Smith, T.  et al.
(2019)  Biorxiv 

DOI: 10.1101/404970

Reaction

Chain : B
UniProt : O82415 (TYDC_PAPSO)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + L-tyrosine = CO2 + tyramine 4.1.1.25 PubMed:23204519
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