PDB ID: 6EEA
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Structure summary
Code : | 6EEA PDBj RCSB PDB PDBe | ||||||||||||
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Header : | LYASE/LYASE inhibitor | ||||||||||||
Title : | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. | ||||||||||||
Release Data : | 2018-11-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Singh, S., McKenna, R., Supuran, C.T., Nocentini, A., Lomelino, C., Lucarini, E., Bartolucci, G., Mannelli, L.D.C., Ghelardini, C., Gratteri, P. | ||||||||||||
Keywords : | Hypoxia, carbonic anhydrase IX, carbonic anhydrase XII, inhibition, anti-proliferative., LYASE, LYASE-LYASE inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.6300 Å ) | ||||||||||||
Citation : |
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.
Nocentini, A.,Trallori, E.,Singh, S.
et al.
PubMed: 30433782 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P00918 (CAH2_HUMAN) | ||||||||||||
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