Het-PDB Navi2 (PDB: 6EE6)

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Ligands
Code	Name	Link
GOL	Glycerol	PoSSuM
J4P	(2r)-2-[(cyclopentylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide	PoSSuM
MG	Magnesium ion	PoSSuM
ZN	Zinc ion	PoSSuM

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Download interaction data: 6EE6

Code :

6EE6 PDBj RCSB PDB PDBe

Header :

hydrolase/hydrolase inhibitor

Title :

X-ray crystal structure of Pf-M1 in complex with inhibitor (6o) and catalytic zinc ion

Release Data :

2018-12-26

Compound :

mol_id	molecule	chains	synonym
1	M1 family aminopeptidase	A	Pfa-M1
	ec: 3.4.11.- fragment: UNP residues 196-1084 mutation: N213Q, N223Q, H378P, N501Q, N745Q, N795Q, N1069Q

Source :

mol_id	organism_scientific	expression_system
1	Plasmodium falciparum (isolate FcB1 / Columbia) (taxid:186763)	Escherichia coli (taxid:562)
	strain: isolate FcB1 / Columbia expression_system_strain: BL21 expression_system_vector_type: PTRCHIS-2B

Authors :

Drinkwater, N., McGowan, S.

Keywords :

M1 ALANYL-AMINOPEPTIDASE, PROTEASE, INHIBITOR, HYDROXAMIC ACID, HYDROLASE, hydrolase-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.5000 Å )

Citation :

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh, N.B.,Drinkwater, N.,Malcolm, T.R. et al.
(2019) J. Med. Chem. 62 : 622 - 640

PDB ID: 6EE6