Brand  (β version)

PDB ID: 6EE2

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Ligands
Code Name Style Show Link
CO3 Carbonate ion PoSSuM
ZN Zinc ion PoSSuM
J1V N-[(1r)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]cyclohexanecarboxamide PoSSuM
SO4 Sulfate ion PoSSuM
1PE Pentaethylene glycol PoSSuM
DMS Dimethyl sulfoxide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6EE2   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : X-ray crystal structure of Pf-M17 in complex with inhibitor 6i and regulatory zinc ion
Release Data : 2018-12-26
Compound :
mol_id molecule chains
1 Pf-M17 A,B,C,D,E,F,G,H,I,J,K,L
fragment: UNP residues 85-605
mutation: N152Q,N515Q,N563Q
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum NF135/5.C10  (taxid:1036726) Escherichia coli  (taxid:562)
gene: PFNF135_05834
expression_system_strain: BL21
expression_system_vector_type: PTRCHIS-2B
Authors : Drinkwater, N., McGowan, S.
Keywords : M17 LEUCYL-AMINOPEPTIDASE, PROTEASE, INHIBITOR, HYDROXAMIC ACID, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh, N.B.,Drinkwater, N.,Malcolm, T.R.  et al.
(2019)  J. Med. Chem.  62 : 622 - 640

PubMed: 30537832
DOI: 10.1021/acs.jmedchem.8b01310

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : W4I9J7 (W4I9J7_PLAFA)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. 3.4.11.1 ARBA:ARBA00000135
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