Het-PDB Navi2 (PDB: 6EDL)

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Ligands
Code	Name		Style	Show	Link
J4M	N-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-B]pyridazin-6-amine				PoSSuM

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Download interaction data: 6EDL

Code :

6EDL PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-B]pyridazin-6-amine

Release Data :

2019-05-01

Compound :

mol_id	molecule	chains	synonym
1	ALK tyrosine kinase receptor	A	Anaplastic lymphoma kinase
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Unidentified baculovirus (taxid:10469)
	gene: ALK

Authors :

Lane, W., Saikatendu, K.

Keywords :

Inhibitor, complex, kinase, sbdd, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.799 Å )

Citation :

Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.

Fushimi, M.,Fujimori, I.,Wakabayashi, T. et al.
(2019) J.Med.Chem. 62 : 4915 - 4935

Chain :

UniProt :

Q9UM73 (ALK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:30061385, PubMed:34819673
	-	PROSITE-ProRule:PRU10028, PubMed:30061385, PubMed:34819673

PDB ID: 6EDL