PDB ID: 6ECZ
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
J4D | 1-[3-nitro-2-oxidanyl-5-[oxidanyl(oxidanylidene)-$L^{4}-azanyl]sulfonyl-phenyl]-3-[2,3,4,5,6-pentakis(fluoranyl)phenyl]urea | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|
Download interaction data: 6ECZ
Structure summary
Code : | 6ECZ PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | LYASE/LYAS INHIBITOR | ||||||||||||
Title : | Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. | ||||||||||||
Release Data : | 2018-11-28 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Singh, S., McKenna, R., Supuran, C.T., Nocentini, A., Lomelino, C., Lucarini, E., Bartolucci, G., Mannelli, L.D.C., Ghelardini, C., Gratteri, P. | ||||||||||||
Keywords : | Hypoxia, carbonic anhydrase IX, carbonic anhydrase XII, inhibition, anti-proliferative., LYASE, LYASE-LYAS INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.210 Å ) | ||||||||||||
Citation : |
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.
Nocentini, A.,Trallori, E.,Singh, S.
et al.
PubMed: 30433782 |
Reaction
Chain : | A | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProt : | P00918 (CAH2_HUMAN) | ||||||||||||
|