Het-PDB Navi2 (PDB: 6E99)

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Ligands
Code	Name		Style	Show	Link
J0G	2-[(2-aminoethyl)amino]-N-[(1r)-1-(3-methoxyphenyl)ethyl]-4-(pyridin-4-yl)benzamide				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine
TPO	Phosphothreonine

Glycosylation
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Download interaction data: 6E99

Code :

6E99 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of Protein Kinase A in complex with the PKI peptide and an amino-pyridinylbenzamide based inhibitor.

Release Data :

2018-11-14

Compound :

mol_id	molecule	chains	synonym
1	cAMP-dependent protein kinase catalytic subunit alpha	A	PKA C-alpha
	ec: 2.7.11.11

mol_id	molecule	chains	synonym
2	PKI peptide	B	PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bos taurus (taxid:9913)	Bovine	Escherichia coli (taxid:562)
	gene: PRKACA

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Judge, R.A., Hobson, A.D.

Keywords :

Protein Kinase A, kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.8800 Å )

Citation :

Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.

Hobson, A.D.,Judge, R.A.,Aguirre, A.L. et al.
(2018) J. Med. Chem. 61 : 11074 - 11100

Chain :

UniProt :

P00517 (KAPCA_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.11	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.11	-
	-	-

PDB ID: 6E99