Brand  (β version)

PDB ID: 6E54

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
HUM (2s)-4-{4-[4-(benzyloxy)-2-fluorophenyl]-2-oxopyridin-1(2h)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide PoSSuM
JCG (2r)-4-{4-[4-(benzyloxy)-2-fluorophenyl]-2-oxopyridin-1(2h)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6E54   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802
Release Data : 2019-06-26
Compound :
mol_id molecule chains synonym
1 UDP-3-O-acyl-N-acetylglucosamine deacetylase A UDP-3-O-acyl-GlcNAc deacetylase,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
ec: 3.5.1.108
fragment: PsaeA.00166.a.DG15
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:208964) Escherichia coli  (taxid:562)
strain: ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
gene: lpxC, envA, PA4406
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PsaeA.00166.a.DG15
Authors : Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : inhibitor, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, LpxC, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.650 Å )
Citation :

Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802

Delker, S.L.,Mayclin, S.J.,Phan, J.N.  et al.
to be published 

Reaction

Chain : A
UniProt : P47205 (LPXC_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388, PubMed:9068651
-