Brand  (β version)

PDB ID: 6E47

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Ligands
Code Name Style Show Link
CHO Glycochenodeoxycholic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6E47   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : Crystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf Receptor and Glycochenodeoxycholic Acid
Release Data : 2018-09-12
Compound :
mol_id molecule chains synonym
1 VP1 P domain A,B VP1
fragment: VP1 Protruding domain (UNP residues 229-530)
mol_id molecule chains synonym
2 CMRF35-like molecule 1 F,G CLM-1, CD300 antigen-like family member F, Leukocyte mono-Ig-like receptor 3, Myeloid-associated immunoglobulin-like receptor 5, MAIR-V
fragment: CD300lf ectodomain (UNP residues 20-131)
Source :
mol_id organism_scientific expression_system
1 Murine norovirus 1  (taxid:223997) Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_vector_type: plasmid
expression_system_plasmid: pET21a(+)
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) Mouse Escherichia coli BL21(DE3)  (taxid:469008)
gene: CD300lf, CLM1, DIR2, IREM1, LMIR3, PIGR3, IgSF13
expression_system_vector_type: plasmid
expression_system_plasmid: pET21a(+)
Authors : Nelson, C.A., Fremont, D.H.
Keywords : Norovirus, Capsid protein, Protruding domain, bile acid, VIRAL PROTEIN, GCDCA, myeloid receptor, CMRF-35-like molecule-1, CLM-1, CLM1, DIR2, IREM1, LMIR3, PIGR3, IgSF13
Exp. method : X-RAY DIFFRACTION ( 1.9500 Å )
Citation :

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.

Nelson, C.A.,Wilen, C.B.,Dai, Y.N.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : E9201 - E9210

PubMed: 30194229
DOI: 10.1073/pnas.1805797115

Reaction

Chain : A, B
UniProt : Q80J94 (Q80J94_MNV1)
Reaction : -
Chain : F, G
UniProt : Q6SJQ7 (CLM1_MOUSE)
Reaction : -