Brand  (β version)

PDB ID: 6E0B

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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide PoSSuM
GOL Glycerol PoSSuM
JZ8 5-methyl-7-(naphthalen-2-ylamino)-1h-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium PoSSuM
LDA Lauryl dimethylamine-N-oxide PoSSuM
ORO Orotic acid PoSSuM
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Structure summary

Code : 6E0B   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1
Release Data : 2018-11-14
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
fragment: UNP residues 158-569 with 384-413 deleted
mutation: C276F
Source :
mol_id organism_scientific organism_common expression_system
1 Plasmodium falciparum  (taxid:36329) Isolate 3D7 Escherichia coli K-12  (taxid:83333)
gene: PFF0160c
expression_system_strain: K-12
expression_system_vector_type: plasmid
expression_system_plasmid: pET28B
Authors : Tomchick, D.R., Phillips, M.A., Deng, X.
Keywords : PLASMODIUM FALCIPARUM, DIHYDROOROTATE DEHYDROGENASE, TRIAZOLOPYRIMIDINE, INHIBITOR, DSM1, FAD, FLAVOPROTEIN, MEMBRANE, MITOCHONDRION, MITOCHONDRION INNER MEMBRANE, OXIDOREDUCTASE, PYRIMIDINE BIOSYNTHESIS, TRANSIT PEPTIDE
Exp. method : X-RAY DIFFRACTION ( 2.0990 Å )
Citation :

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

White, J.,Dhingra, S.K.,Deng, X.  et al.
(2019)  ACS Infect Dis  5 : 90 - 101

PubMed: 30375858
DOI: 10.1021/acsinfecdis.8b00211

Reaction

Chain : A
UniProt : Q08210 (PYRD_PLAF7)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 -
-