Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
K Potassium ion
F0G (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine
P33 3,6,9,12,15,18-hexaoxaicosane-1,20-diol
PP3 Alanyl-pyridoxal-5'-phosphate
Code : 6DYT
Header : LYASE
Title : Citrobacter freundii tyrosine phenol-lyase F448A mutant complexed with L-alanine
Release Data : 2018-10-10
Compound :
mol_id molecule chains synonym
1 Tyrosine phenol-lyase A,B Beta-tyrosinase
ec: 4.1.99.2
mutation: F448A
Source :
mol_id organism_scientific expression_system
1 Citrobacter freundii  (taxid:546) Escherichia coli  (taxid:469008)
atcc: 29063
gene: tpl
expression_system_strain: BL21(DE3)
Authors : Phillips, R.S.
Keywords : pyridoxal-5'-phosphate, aminotransferase fold, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.0500 Å )
Citation :

Crystal Structures of Wild-Type and F448A Mutant Citrobacter freundii Tyrosine Phenol-Lyase Complexed with a Substrate and Inhibitors: Implications for the Reaction Mechanism.

Phillips, R.S.,Craig, S.
(2018)  Biochemistry  57 : 6166 - 6179

PubMed: 30260636
DOI: 10.1021/acs.biochem.8b00724

Chain : A, B
UniProt : P31013 (TPL_CITFR)
Reaction : L-tyrosine + H(2)O = phenol + pyruvate + NH(3).