Brand  (β version)

PDB ID: 6DUK

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
ANP Phosphoaminophosphonic acid-adenylate ester PoSSuM
JBJ (2r)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2h-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide PoSSuM
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Structure summary

Code : 6DUK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : EGFR with an allosteric inhibitor
Release Data : 2019-06-05
Compound :
mol_id molecule chains synonym
1 Epidermal growth factor receptor A,B,C,D,E,F Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
ec: 2.7.10.1
mutation: T790M, V948R
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: EGFR, ERBB, ERBB1, HER1
Authors : Park, E., Eck, M.J.
Keywords : Allosteric inhibitor, EGFR, ONCOPROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.

To, C.,Jang, J.,Chen, T.  et al.
(2019)  Cancer Discov  9 : 926 - 943

PubMed: 31092401
DOI: 10.1158/2159-8290.CD-18-0903

Reaction

Chain : A, B, C, D, E, F
UniProt : P00533 (EGFR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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