Brand  (β version)

PDB ID: 6DM0

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Ligands
Code Name Style Show Link
CYZ Cyclothiazide PoSSuM
GLU Glutamic acid PoSSuM
GZD N,N,N-trimethyl-5-({[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)pentan-1-aminium PoSSuM
Non-standard Residues
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Structure summary

Code : 6DM0   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction
Release Data : 2018-08-22
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit A,B,C,D GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: CACNG2
Authors : Twomey, E.C., Yelshanskaya, M.V., Vassilevski, A.A., Sobolevsky, A.I.
Keywords : Ion channel, TRANSPORT PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 4.4 Å )
Citation :

Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.

Twomey, E.C.,Yelshanskaya, M.V.,Vassilevski, A.A.  et al.
(2018)  Neuron  99 : 956 - 968.e4

PubMed: 30122377
DOI: 10.1016/j.neuron.2018.07.027

Reaction

Chain : A, B, C, D
UniProt : P19491 (GRIA2_RAT)
Reaction: EC: Evidence:
Physiological Direction:
Ca(2+)(in) = Ca(2+)(out) - PubMed:11773314, PubMed:1653450
-
Na(+)(in) = Na(+)(out) - PubMed:11773314, PubMed:1653450
-
Chain : A, B, C, D
UniProt : Q9Y698 (CCG2_HUMAN)
Reaction : -