Brand  (β version)

PDB ID: 6DKB

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Ligands
Code Name Style Show Link
FKY 2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1h-imidazol-4-yl)pyridine-3-carboxamide PoSSuM
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Structure summary

Code : 6DKB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10b.
Release Data : 2018-07-11
Compound :
mol_id molecule chains synonym
1 High affinity nerve growth factor receptor A Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: NTRK1, MTC, TRK, TRKA
expression_system_vector_type: pKRIC-N6
Authors : Greasley, S.E., Johnson, E., Kraus, M.L., Cronin, C.N.
Keywords : Inhibitor Tyrosine kinase, TRANSFERASE, pan-Trk Kinase, Treatment for pain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.68 Å )
Citation :

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Bagal, S.K.,Andrews, M.,Bechle, B.M.  et al.
(2018)  J. Med. Chem.  61 : 6779 - 6800

PubMed: 29944371
DOI: 10.1021/acs.jmedchem.8b00633

Reaction

Chain : A
UniProt : P04629 (NTRK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:1281417, PubMed:2927393
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