Het-PDB Navi2 (PDB: 6DDI)

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Ligands
Code	Name	Link
G7V	4-{[(2s,4r)-1-acetyl-2-methyl-6-(1h-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile	PoSSuM
SO4	Sulfate ion	PoSSuM
EDO	1,2-ethanediol	PoSSuM
03S	Methanesulfonic acid	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6DDI

Code :

6DDI PDBj RCSB PDB PDBe

Header :

Transcription/Inhibitor

Title :

Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue

Release Data :

2019-11-13

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 2	A,B,C	O27.1.1,Really interesting new gene 3 protein

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: BRD2, KIAA9001, RING3 expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: pET28a(+)

Authors :

White, S.W., Yun, M.

Keywords :

BET, BRD2, bromodomain, Inhibitor, Complex, Transcription, Transcription-Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.

Slavish, P.J.,Chi, L.,Yun, M.K. et al.
(2020) Cancer Res. 80 : 3507 - 3518

PDB ID: 6DDI