Brand  (β version)

PDB ID: 6D6U

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Ligands
Code Name Style Show Link
ABU Gamma-amino-butanoic acid PoSSuM
FYP Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate PoSSuM
Y01 Cholesterol hemisuccinate PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 6D6U   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A
Release Data : 2018-06-27
Compound :
mol_id molecule chains synonym
1 Gamma-aminobutyric acid receptor subunit beta-2,Gamma-aminobutyric acid receptor subunit beta-2 A,C GABA(A) receptor subunit beta-2,GABA(A) receptor subunit beta-2
mol_id molecule chains synonym
2 Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1 B,D GABA(A) receptor subunit alpha-1,GABA(A) receptor subunit alpha-1
mol_id molecule chains synonym
3 Gamma-aminobutyric acid receptor subunit gamma-2,Gamma-aminobutyric acid receptor subunit gamma-2 E GABA(A) receptor subunit gamma-2,GABA(A) receptor subunit gamma-2
mol_id molecule chains
4 Kappa Fab Light Chain I,L
mol_id molecule chains
5 IgG2b Fab Heavy Chain J,K
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: GABRB2
expression_system_common: Human
expression_system_variant: GnTI-
expression_system_cell_line: HEK293
expression_system_atcc_number: CRL-3022
expression_system_plasmid: pEZT-BM
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: GABRA1
expression_system_common: Human
expression_system_variant: GnTI-
expression_system_cell_line: HEK293
expression_system_atcc_number: CRL-3022
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: GABRG2
expression_system_common: Human
expression_system_variant: GnTI-
expression_system_cell_line: HEK293
expression_system_atcc_number: CRL-3022
expression_system_plasmid: pEZT-BM
mol_id organism_scientific organism_common
4 Mus musculus  (taxid:10090) House mouse
strain: BALB/c
mol_id organism_scientific organism_common
5 Mus musculus  (taxid:10090) House mouse
strain: BALB/c
Authors : Zhu, S., Noviello, C.M., Teng, J., Walsh Jr, R.M., Kim, J.J., Hibbs, R.E.
Keywords : Ligand-gated ion channel, GABA-A receptor, Cys-loop receptor, TRANSPORT PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 3.92 Å )
Citation :

Structure of a human synaptic GABAAreceptor.

Zhu, S.,Noviello, C.M.,Teng, J.  et al.
(2018)  Nature  559 : 67 - 72

PubMed: 29950725
DOI: 10.1038/s41586-018-0255-3

Reaction

Chain : A, C
UniProt : P47870 (GBRB2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride(in) = chloride(out) - UniProtKB:P08219
-
Chain : B, D
UniProt : P14867 (GBRA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride(in) = chloride(out) - PubMed:23909897, PubMed:29950725, PubMed:30602789
-
Chain : E
UniProt : P18507 (GBRG2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride(in) = chloride(out) - PubMed:14993607, PubMed:16412217, PubMed:2538761, PubMed:27864268, PubMed:29950725, PubMed:30602789
-