Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
CL Chloride ion
FMT Formic acid
FVG 1-[(2s)-1-{6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1h-benzimidazol-4-yl}pyrrolidin-2-yl]methanamine
GNP Phosphoaminophosphonic acid-guanylate ester
GOL Glycerol
MG Magnesium ion
NA Sodium ion
Modified Residues
Code Name Link
CSO S-hydroxycysteine
Code : 6D5E
Title : Ras:SOS:Ras in complex with a small molecule activator
Release Data : 2018-09-19
Compound :
mol_id molecule chains synonym
1 GTPase HRas A H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
mutation: Y64A
mol_id molecule chains synonym
2 Son of sevenless homolog 1 B SOS-1
mol_id molecule chains synonym
3 GTPase HRas C H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HRAS, HRAS1
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SOS1
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HRAS, HRAS1
Authors : Phan, J., Hodges, T., Fesik, S.W.
Keywords : Ras, SOS, inhibitor, ONCOPROTEIN, Protein-protein complex, MAPK, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

Hodges, T.R.,Abbott, J.R.,Little, A.J.  et al.
(2018)  J. Med. Chem.  61 : 8875 - 8894

PubMed: 30205005
DOI: 10.1021/acs.jmedchem.8b01108

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.

Burns, M.C.,Sun, Q.,Daniels, R.N.  et al.
(2014)  Proc. Natl. Acad. Sci. U.S.A.  111 : 3401 - 3406

PubMed: 24550516
DOI: 10.1073/pnas.1315798111

Chain : C
UniProt : P01112 (RASH_HUMAN)
Reaction : -
Chain : B
UniProt : Q07889 (SOS1_HUMAN)
Reaction : -