Brand  (β version)

PDB ID: 6D26

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Ligands
Code Name Style Show Link
FSY Fevipiprant PoSSuM
OLA Oleic acid PoSSuM
PGE Triethylene glycol PoSSuM
PGO S-1,2-propanediol PoSSuM
SIN Succinic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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YCM S-(2-amino-2-oxoethyl)-L-cysteine
Glycosylation
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Structure summary

Code : 6D26   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN/ANTAGONIST
Title : Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant
Release Data : 2018-10-03
Compound :
mol_id molecule chains synonym
1 Prostaglandin D2 receptor 2, Endolysin chimera A Chemoattractant receptor-homologous molecule expressed on Th2 cells,G-protein coupled receptor 44,Lysis protein,Lysozyme,Muramidase
fragment: CRTH2 (UNP residues 1-236), T4 ligase (UNP residues 2-12,61-161), CRTH2 (UNP residues 238-339)
mutation: N25A,G237ADLGLQHR,A1298C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTGDR2, CRTH2, DL1R, GPR44
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
Authors : Wang, L., Yao, D., Deepak, K., Liu, H., Gong, W., Fan, H., Wei, Z., Zhang, C.
Keywords : GPCR, MEMBRANE PROTEIN-ANTAGONIST complex
Exp. method : X-RAY DIFFRACTION ( 2.7980 Å )
Citation :

Structures of the Human PGD2Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.

Wang, L.,Yao, D.,Deepak, R.N.V.K.  et al.
(2018)  Mol. Cell  72 : 48 - 59.e4

PubMed: 30220562
DOI: 10.1016/j.molcel.2018.08.009

Reaction

Chain : A
UniProt : Q9Y5Y4 (PD2R2_HUMAN)
Reaction : -
Chain : A
UniProt : D9IEF7 (D9IEF7_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 ARBA:ARBA00000632, HAMAP-Rule:MF_04110, RuleBase:RU003788
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