Het-PDB Navi2 (PDB: 6D1Y)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
FQJ	2,4-dichloro-N-(3-methyl-1-phenyl-1h-pyrazol-5-yl)benzamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6D1Y

Code :

6D1Y PDBj RCSB PDB PDBe

Header :

TRANSFERASE/Inhibitor

Title :

Crystal structure of Tyrosine-protein kinase receptor in complex with 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide Inhibitor

Release Data :

2018-05-02

Compound :

mol_id	molecule	chains	synonym
1	High affinity nerve growth factor receptor	A	Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Insect cell expression vector pTIE1 (taxid:266783)
	gene: NTRK1, MTC, TRK, TRKA expression_system_vector_type: pKRIC-N6

Authors :

Greasley, S.E., Johnson, E., Kraus, M.L., Cronin, C.N.

Keywords :

Allostric Inhibitor Tyrosine kinase, TRANSFERASE, TRANSFERASE-Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.9300 Å )

Citation :

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

Bagal, S.K.,Omoto, K.,Blakemore, D.C. et al.
(2019) J. Med. Chem. 62 : 247 - 265

Chain :

UniProt :

P04629 (NTRK1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:1281417, PubMed:2927393
	-	PROSITE-ProRule:PRU10028, PubMed:1281417, PubMed:2927393

PDB ID: 6D1Y