Het-PDB Navi2 (PDB: 6D0M)

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Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
GOL	Glycerol				PoSSuM

Non-standard Residues
Code	Name	Show
CAR	Cytosine arabinose-5'-phosphate

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 6D0M

Code :

6D0M PDBj RCSB PDB PDBe

Header :

TRANSFERASE/DNA

Title :

Polymerase Eta post-insertion binary complex with cytarabine (AraC)

Release Data :

2018-09-05

Compound :

mol_id	molecule	chains	synonym
1	DNA polymerase eta	A	RAD30 homolog A,Xeroderma pigmentosum variant type protein
	ec: 2.7.7.7 fragment: residues 1-432 mutation: C406M

mol_id	molecule	chains
2	DNA (5'-D(CPAPTPGPAPCPAPGPTPGPCPT)-3')	T
	other_details: DNA template strand

mol_id	molecule	chains
3	DNA/RNA (5'-D(APGPCPAPCPTPGPT)-R(P*(CAR))-3')	P
	other_details: DNA primer strand

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: POLH, RAD30, RAD30A, XPV expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: PET28

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes other_details: Engineered

mol_id	organism_scientific
3	Synthetic construct (taxid:32630)
	synthetic: yes other_details: Engineered

Authors :

Rechkoblit, O., Aggarwal, A.K.

Keywords :

Cytarabine, AraC, DNA damage, Translesion, DNA synthesis, DNA Replication, TRANSFERASE, TRANSFERASE-DNA complex

Exp. method :

X-RAY DIFFRACTION ( 1.832 Å )

Citation :

Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.

Rechkoblit, O.,Choudhury, J.R.,Buku, A. et al.
(2018) Sci Rep 8 : 12702 - 12702

PDB ID: 6D0M